Inline purification in continuous flow synthesis – opportunities and challenges

This paper from University College Dublin does a great job of highlighting flow technologies that have addressed or have yet to address common workup steps in chemical synthesis. Zaiput’s separators were the primary focus of the Inline extractions/separations section where they were identified as the key technology in this space. The article also highlighted what they perceived to be a major shortcoming in Zaiput’s technology – the scalability of flow rates and challenges with solid accumulation. Since this writing, Zaiput has addressed these concerns by releasing a large scale 40 L/min separator and focused on prefiltration techniques to minimize fouling concerns. Today the scalability is direct and easily done from the lab to production.