Back Pressure Regulators

  • Plug-and-play
  • Work with multiphasic conditions
  • Clog-resistant
  • User-selected back pressure


Zaiput Flow Technologies’ back pressure regulators are specifically designed for the needs of the flow chemist. Our devices feature a unique combination of high accuracy and precision, broad pressure range and outstanding chemical compatibility in a compact format.

The back pressure regulator compares the pressure of the fluid to be controlled (main stream) to a reference pressure. Flow of the main stream is allowed only if its pressure meets the reference pressure.

In addition, our pressure regulators have the unique feature that the set point is selected by the user. The user selects the back pressure set point by pressurizing air inside a dedicated chamber of the device. The set point is equal to the pressure of the air inside the device.


  • Metal-free wetted parts
  • Very accurate and precise (1%)
    Error < 1% across flow rates of 0-1000ml/min
  • Adjustable set point
    Users can simply set any pressure for the BPRs by adjusting the pressure of the compressed air chamber
  • Excellent for gas-liquid streams
    Zaiput’s BPRs are designed to function with a stream containing gas, liquid, or multiphase.
  • Robust to clogging
    Our devices eliminate extremely small orifices, which can cause clogging and over-pressurizing.

Other Advantages

  • Potential use as a relief valve
    Zaiput’s BPRs can prevent a flow process from over-pressurization. They can function as a relief valve
  • Excellent compatibility
    Machined in materials with excellent chemical resistance (e.g. ETFE and PFA), Zaiput’s BPRs works with a wide range of organic solvents, as well as acidic and basic solutions.
  • Easy to install and implement into any process pipeline
    Zaiput’s BPRs can be installed and implemented easily into any process pipeline.

How It Works

Pressurize your fluid flow with the Zaiput BPR

The Zaiput BPRs employ a dome-loaded type. Pressurization happens as a fluid needs to work against the compressed gas chamber in order to flow out on the other side. Zaiput’s BPRs are carefully designed with chemically compatible materials as well as a reliable dynamic response of an elastic sheet. With a sealed valve, the BPRs can be used in two modes:

Mode 1: Set it and forget it

In this mode, the user compresses gas into the chamber of the device at any certain pressure P. Then, the user manually closes the valve; P inside the chamber is now at the set point. The user can disconnect the BPR from the pressure source (e.g., gas tank). If another set point is required, this procedure can be repeated by setting the pressure of the top chamber to the new value.

Mode 2: Continuous set point

Some processes require the fluid pressure to dynamically change over the course of operation. The Zaiput BPR is able to provide such a continuous pressure setting. To achieve this setting, the user connects the Zaiput BPR to the gas/pressure source. Note that the valve is left open. By changing the pressure of the gas source (e.g., the regulator of the gas tank), the set point or P is dynamically changed.

Note that the Zaiput BPR sets a minimum level of pressure for the main fluid flow. If multiple BPRs are placed in series, the pressure of the fluid flow will be equal to the highest pressure set point (i.e., not the sum of the multiple set points). As a result, the device can also be used as a relief valve. Each BPR comes with a connection tube (the external pressurized gas source is not included).

Performance with varying phases and flow rates

The plots below illustrate the pressure recorded at the inlet of the our back pressure regulator BPR-10 for different pressure set points and different flow rates, for both liquid and gas streams.

Flow rates exceeding what are recommended can be applied, but they will result in a larger error in the pressure set point.


Zhiguo Wang, Romaric Gérardy, Guillaume Gauron, Christian Damblon and Jean-Christophe M Monbaliu, Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions Reaction Chemistry & Engineering Oct 2018.

Irini Abdiaj, Clemens R. Horn, and Jesus Alcazar, Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring The Journal of Organic Chemistry Oct 2018.

Gaowei Wu, Enhong Cao, Peter Ellis, Achilleas Constantinou, Simon Kuhn, Asterios Gavriilidis, Development of a flat membrane microchannel packed-bed reactor for scalable aerobic oxidation of benzyl alcohol in flow Chemical Engineering Journal Oct 2018.

Nelly Ntumba Tshibalonza, Romaric Gérardy, Zouheir Alsafra, Gauthier Eppeb and Jean-Christophe M. Monbaliu,
A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol
Green Chemistry
Sep 2018.

Carlos Mendoza Noémie Emmanuel Carlos Paez Laurent Dreesen Jean-Christophe M. Monbaliu, and Benoît Heinrichs, Improving Continuous Flow Singlet Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles ChemPhotoChem Aug 2018.

Nathalie Ollivier, Thomas Toupy, Ruben C. Hartkoorn, Rémi Desmet, Jean-Christophe M. Monbaliu & Oleg Melnyk, Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides Nature Communications July 2018.

Carlos Mendoza, Noémie Emmanuel, Carlos Alberto Páez, Laurent Dreesen, Jean-Christophe M. Monbaliu, Benoît Heinrichs, Transitioning from conventional batch to microfluidic processes for the efficient singlet oxygen photooxygenation of methionine J. Photochemistry Dec 2017.

Joshua Britton and Timothy F Jamison, The assembly and use of continuous flow systems for chemical synthesis Nature Protocols Oct 2017.

Amanda C. Wicker, Frank A. Leibfarth and Timothy F. Jamison, Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules Polym. Chem. Sep 2017.

Gaowei Wu, Enhong Cao, Simon Kuhn, and Asterios Gavriilidis, A Novel Approach for Measuring Gas Solubility in Liquids Using a Tube-in-Tube Membrane Contactor Chem. Eng. Technol. Aug 2017.

Róbert Örkényi, Gyula Beke, Eszter Riethmüller, Zoltán Szakács, János Kóti, Ferenc Faigl, János Éles, and István Greiner, Environment-Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques Eur. J. Org. Chem. Aug 2017.

Paul Watts and Cloudius Sagandira, Synthesis of amines, carbamates and amides via multi-step continuous flow synthesis Eur. J. Org. Chem. Aug 2017.

Noémie Emmanuel, Carlos Mendoza, Marc Winter, Clemens R. Horn, Alessandra Vizza, Laurent Dreesen, Benoît Heinrichs, and Jean-Christophe M. Monbaliu, Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions Org. Process Res. Dev. July 2017.

Isabel Ortiz de Solorzano, Martin Prieto, Gracia Mendoza, Teresa Alejo, Silvia Irusta, Manuel Arruebo, and Victor Sebastian, Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulphide Nanoparticles ACS Appl. Mater. Interfaces Aug 2016.

Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and extraction  Org. Process Res. Dev. Aug 2016.

Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam, Jie Chen, Timothy F. Jamison, Klavs F. Jensen, Jean-Christophe M. Monbaliu, Allan S. Myerson, Eve M. Revalor, David R. Snead, Torsten Stelzer, Nopphon Weeranoppanant, Shin Yee Wong, Ping Zhang, On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system Science April 2016.

Achilleas Constantinou, Gaowei Wu, Albert Corredera, Peter Ellis, Donald Bethell, Graham J. Hutchings, Simon Kuhn, and Asterios Gavriilidis, Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed-Bed Reactor Organic Process Research & Development December 2015.

Chunhui Dai, David R. Snead, Ping Zhang, and Timothy F. Jamison, Continuous-Flow Syn and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities J. Flow Chem. July 2015.

David Snead, Timothy Jamison, A Three‐Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous‐Flow Processing. AngewandteChemie, Dec 2014.


Product BPR-10 BPR-1000
Total Flow Rate 0.05-20 ml/min (for high accuracy) 20-1000 ml/min (for high accuracy)
Max Set Point Pressure 2 MPa (290 psi) 2 MPa (290 psi)
Dimensions 52 x 52 x 44 mm 97 x 97 x 64 mm
Max Inlet Pressure 5 MPa 5 MPa
Max Operating Temp 130 ℃ 130 ℃
Process Fluid Ports 1/4″ UNF – 28 flat bottom 1/4″ OD tubing with Swagelok PFA fittings and our compression nut
Wetted parts Perfluorinated polymers (ETFA, PFA) Perfluorinated polymers (ETFA, PFA)
Error < 1% < 1%

*Scroll left to see more of the table

Ordering Information

FAQs about the Zaiput back pressure regulator (BPR)

Can Zaiput back pressure regulators (BPRs) handle multiphasic fluids?

Zaiput BPRs work well with multiphasic fluids such as liquid/liquid and gas/liquid. They are also capable of handling small amounts of solid particles with diameters smaller than 150-200 μl.

How precise are the Zaiput BPRs?

The set point of the Zaiput BPRs are adjustable by compressed air/gas. The Zaiput BPR have been designed to maintain a stable pressure with negligible variation (± 5%).

How do I connect a Zaiput BPR into my process?

The inlet and outlet of the Zaiput BPR-10 and BPR-1000 are listed in the specifications tab.

How often do I have to reset the Zaiput BPR?

Zaiput BPRs are designed to be leak-proof. They have been characterized to be able to maintain a stable pressure for at least 10 days.

What are the differences between a back pressure regulator and a pressure regulator?

A back pressure regulator is used to regulate inlet pressure, so an upstream fluid will be pressurized to the set point. On the other hand, a pressure regulator regulates outlet pressure, so a downstream fluid will be pressurized to the set point.

What makes the Zaiput BPRs unique?

Unlike many other products on the market, Zaiput BPRs do not come with a factory-preset pressure. Instead, users are allowed to precisely set the Zaiput BPR to any pressure within a recommended operating range (1 – 290 psi). Zaiput BPRs are also easy-to-use and chemically compatible.

Are the Zaiput BPRs acid-resistant?

All of the wetted parts inside the Zaiput BPR are made of highly chemical-compatible materials. The metal shell will not be in contact with the fluid. They can handle most organic solvents as well as acidic solutions. Contact our technical support team for questions about chemical compatibility.

What are the minimum and maximum flow rates that can be operated by the Zaiput BPR?

The recommended operating flow rate is between 0 and 1000 mL/min, depending on the unit.

Can the Zaiput BPR be heated for some solid handling applications?

The internal parts of Zaiput BPRs are made of polymers. Therefore, the recommended operating temperature is below 130 ˚C. For any application at higher temperatures, consult our service team for a customized solution.