News and Events

An innovative sequential flow platform for automated multi-step chemical processes

Development of an automated platform for the synthesis, extraction, and purification of chemical compounds using optimal synthetic routes

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Extractive Technology Innovations for the Metal Recycling Industry

#Recycling metals, especially #RareEarthElements, and other precious metals are a critical industry for both environmental and economic sustainability for countries around the world. How will the industry #innovate as the demand for these valuable metals continues to outstrip supply? This blog post dives into how Zaiput can solve challenges facing the industry.   CLICK HERE TO READ POST

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Fast Isomerization before Isomerization-Hydroformylation Probing the Neglected Period with a Novel Microfluidic Device

A very common use case for Zaiputs’ separators is in gas/liquid separations following hydrogenation reactions. These reactions are commonly run in the presence of excess hydrogen to push the reaction toward completion, but this excess hydrogen needs to be separated from the liquid stream post-reaction. Zaiput separators’ small internal volume and high performance make this […]

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Inline purification in continuous flow synthesis – opportunities and challenges

This paper from University College Dublin does a great job of highlighting flow technologies that have addressed or have yet to address common workup steps in chemical synthesis. Zaiput’s separators were the primary focus of the Inline extractions/separations section where they were identified as the key technology in this space. The article also highlighted what […]

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Laboratory Scale Continuous Flow Systems for the Enantioselective Phase Transfer Catalytic Synthesis of Quaternary Amino Acids

This paper from Universita degli Studi di Milano and Taros Chemicals demonstrates how stereoselective phase transfer catalysis can be brought into flow. These systems show gains in productivity and space time yield compared to batch processing while simplifying the process. Zaiput’s separator enables an in-line work between reactive steps for a true flow synthesis process. […]

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Effect of dilution on the performance of ionic liquids in milliflow solvent extraction applications: Towards integration of extraction, scrubbing and stripping operations with in-line membrane-based phase separation

This paper from researchers at KU Leuven demonstrates various capabilities of ionic liquids and their applicability with Zaiput Flow Technologies in line separators.

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Can you double your batch reactors productivity?

Zaiput’s technology featured on the October 2022 release of Chemagazin. Read the article at pages 12-13 at this link: LINK TO CHEMAGAZIN

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SEP-40K is Here!

Zaiput releases large-scale device for plant operations. The 40 L/min separator is designed to speed up batch separations, crush emulsions, and provide a separation solution for large-throughput flow processes.

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Continuous extraction and concentration of secreted metabolites from engineered microbes using membrane technology

Zaiput liquid-liquid separator used in the context of continuous microalgal cultivation and patchoulol extraction   LINK TO FULL PAPER

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Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

Integration of biocatalysis and flow chemistry can make processes greener and more efficient. This paper from Università degli Studi di Milano shows how. In the setup, a Zaiput separator is used so that a continuous flow setup is achieved also for the extractive step LINK TO FULL PAPER

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Biocatalyzed Synthesis of Vanillamides and Evaluation of Their Antimicrobial Activity

A biocatalyzed flow chemistry approach to forming antimicrobial vanillamides provides a more sustainable method of making antimicrobials.   LINK TO FULL PAPER

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Intensified liquid-liquid extraction of biomolecules using ionic liquids in small channels

A fantastic demonstration of the continuous extraction of aminoacids in flow using ionic liquids from researchers at UCL. This highlights the benefits of liquid-liquid extraction with a focus on how ionic liquids can be the solution for LLE in bio-processing. Of course, Zaiput Flow Technologies separators will play a key role in scalable continuous separations for these unique systems.   […]

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Automated and continuous synthesis of drug substances

A brilliant publication where a continuous flow mode was developed for the synthesis of the API mesalazine. A multi-instrument PAT strategy was implemented to equip the full line with in-line monitoring capability for critical quality attributes at several points. Two Zaiput’s SEP-10s were used in two liquid-liquid separation steps to eliminate aqueous and organic waste […]

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Liquid-Liquid extraction with systematically adjusted PH

Flow chemistry as a combination of continuous processing and continuous in-line analytics.

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Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

A brilliant work by the University of Milan showing how Flow Chemistry and Zaiput’s technology can lead to a cost-efficient, environmentally friendly, and sustainable process for the oxidation of Tyrosol (Ty) to hydroxytyrosol (HTy), a compound used in the food, nutraceutical and cosmetic applications   LINK TO THE PAPER

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High-pressure asymmetric hydrogenation in a customized flow reactor and its application in multi-step flow synthesis of chiral drugs

A fantastic demonstration of homogenous asymmetric hydrogenation by researchers at the University of Leeds Hydrogenations are a great fit for flow chemistry due to the explosive nature of high-pressure H2, and it’s great to see Zaiput Flow Technologies separators integrated into these API synthesis processes, enabling safe and continuous separations. Check out the full paper here: https://lnkd.in/eB94_mS

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ZFOX Batch Extraction Platform – Andrea Adamo presentation at Achema Pulse 2021

STARTING IN FLOW BY LEVERAGING YOUR BATCH ASSETS Check out Andrea Adamo’s presentation at Achema Pulse in June 2021: Link to the video on Youtube Z-FOX integrates fast and continuous phase separation with engineered mass transfer to provide a complete extraction solution. Z-FOX is a turnkey platform that allows users to quickly tune their extractions, […]

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Zaiput European Representative

Zaiput is excited to announce the start of a new era for the company with our first formal European presence, marking the establishment of our permanent presence on the continent. Our new representative, Lorenzo Gazzola, originally from Milan, Italy but now located in Prague, Czech Republic, comes from a strong background in sales to the pharmaceutical […]

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Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics

A nice example of Zaiput’s Back Pressure Regulators used in a safe and highly intensified process for the synthesis of  1,5-Disubstituted Tetrazoles.

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Evaluation of a Continuous-Flow Photo-Bromination Using N-Bromosuccinimide for Use in Chemical Manufacture

A continuous-flow photo-bromination using N-Bromosuccinimide, enabled by Zaiput technology

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PHARMA AND FINE CHEMICAL INDUSTRY NEEDS FOR EXTRACTIVE INNOVATION

In an article published just over 10 years ago now, a roundtable from top companies in the pharmaceutical and fine chemical industries highlighted some of the many needs for making chemical manufacturing greener and more sustainable.  

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We’re hiring!

For more information, visit our Careers page!

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In-line Purification Review

Nopphon Weeranoppanant and Andrea Adamo, In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry, ACS Med. Chem. Lett., Dec 2019.

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Article featuring Zaiput’s multistage platform

Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid–Liquid Extraction and Membrane Separation Technology

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Webinar on Flow/Batch Separation

Liquid-Liquid/Gas-Liquid Separation for Continuous and Batch Chemical Processing

Date: Now On-Demand, originally recorded November 27, 2018
Duration: 60-minutes

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Partnership Between Zaiput Flow Technologies and ThalesNano Set to Improve Process Intensification

Zaiput Flow Technologies, a global leader in separation, and ThalesNano, the world leader in bench-top flow chemistry reactors, recently signed a distribution agreement and entered into a technology partnership that exploits the benefits of their combined technologies.

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Science article featuring design concepts from our CEO and leveraging Zaiput technology

Congratulations to our Founder and CEO Andrea Adamo and his colleagues at Massachusetts Institute of Technology for this great publication!

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Announcing BPR-1000

BPR-1000 is our newest back pressure regulator for flow chemists with the same robust, easy to use design of BPR-10 but allowing high accuracy for flow rates up to 1000 ml/min. 

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Zaiput in Space!

Zaiput recently sent its separators to the International Space Station. Learn more about our trip.

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Separating Liquids in Space

Separating Liquids in Space

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SEP-3000 is here!

Our newest separator, SEP-3000, makes scaling from bench to production seamless.

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Drug manufacturing that’s out of this world

Zaiput is working towards drug manufacturing in space

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Zaiput Signs Distribution Agreement with Corning

Zaiput and Corning announce their partnership

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From MIT to Startup in 7 Steps

Zaiput’s CEO talks about the founding of Zaiput

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Vapourtec Zaiput link increases capabilities

Flow chemistry specialists Vapourtec have worked with US-based Zaiput Flow Technologies to add liquid – liquid separation to its product capabilities.

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Zaiput wins the Galactic Grant

The Galactic Grant allows Zaiput to test its separation technology on the International Space Station

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Upcoming Events

Zaiput at ORGANIC PROCESS RESEARCH AND DEVELOPMENT CONFERENCE – Barcelona

October 2, 2023

Zaiput will be at the OPRD CONFERENCE in Barcelona On October 2nd – 4th 2023

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Zaiput at CFRT 2023

September 27, 2023

Zaiput at CFRT 2023 | September 27th – 28th 2023

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Zaiput at CPHI 2023

October 24, 2023

Zaiput at CPHI 2023 – October 24th – 26th 2023

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Zaiput at ILMAC 2023

September 26, 2023

Zaiput at ILMAC 2023 | September 26th – 28th 2023

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Recent Events

Zaiput at Flow Chemistry India Annual Conference

September 14, 2023

Zaiput at Flow Chemistry India Annual Conference on September 14th – 15th

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Zaiput at ILMAC 2023

September 26, 2023

Zaiput at ILMAC 2023 | September 26th – 28th 2023

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Zaiput at Chemspec 2023

May 24, 2023

Zaiput at Chemspec 2023, Stand B190

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