Automated and continuous synthesis of drug substances
A brilliant publication where a continuous flow mode was developed for the synthesis of the API mesalazine. A multi-instrument PAT strategy was implemented to equip the full line with in-line monitoring capability for critical quality attributes at several points.
Two Zaiput’s SEP-10s were used in two liquid-liquid separation steps to eliminate aqueous and organic waste and in a final gas-liquid separation to release excess hydrogen downstream of a hydrogenation.
