Literature with Zaiput
Scientific articles featuring our separators:
Scientific research articles relating to our multistage extraction platform:
Scientific articles featuring our crystallizer:
Scientific articles featuring our back pressure regulators:
Liquid-Liquid Separation
Scientific articles featuring our separators:
Charlotte Pheasey and Panagiota Angeli, Intensified extraction of Nd from a Nd/Fe mixture in small channels for NdFeb magnet recycle, Chemical Engineering Science, 2025
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R. Michael van Dam, Yuji Kuge, Giancarlo Pascali, Automated Technologies for the Development and Production of Radiopharmaceuticals, 2025
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Wei, Dan and Ma, Kai and Ni, Lei and Mebarki, Ahmed and Fu, Gang and Jiang, Juncheng, Thermal Safety Upgrading: Batch-to-Flow Transition of Acid-Catalyzed Tert-Butyl Peroxypivalate Synthesis. 2025
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Molnár, Márk and Fődi, Tamás and Tatai, János and Kun, Vilibald and Balázs, Barbara and Gáti, Tamás and Dargó, Gergő and Nyerges, Miklós, Continuous Flow for the Photochemical Synthesis of 3-Substituted Quinolines, Organic Process Research & Development, 2025
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Yoshii, A., Fujii, A., Nishiyama, Y. et al. Selective synthesis of phenylhydroxylamine under slug flow conditions using Bayesian optimization. J Flow Chem, 2025
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Yiota-Victoria Phakoukaki and Paul O’Shaughnessy and Panagiota Angeli, Continuous intensified selective extraction of platinum group metals in small channels, Separation and Purification Technology, 2025
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Yea Seul Jang and Jong Min Park and Jong Won Lee and Chan Ho Song and Chan Pil Park, Flow heterogeneous catalysis via stable dispersion of silica gel-supported catalysts, Chemical Engineering Journal, 2025
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Allred, Tyler K. and Mukhina, Olga A. and Epstein, Oleg and Yan, Jie and Crossley, Kevin and Beaver, Matthew G. and Frohn, Michael J. and Murray, James I. and Bauer, David, Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation─Application to the Catalytic Asymmetric Cyclopropanation of Substituted Styrenes, Organic Process Research & Development, 2025
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Ljubić, A., Vušak, V., Cingesar, I.K. et al. Application of natural deep eutectic solvents in the continuous process for synthesis of resveratrol analogues by the Wittig reaction. J Flow Chem, 2025
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Marchini, V., Paradisi, F. Self-sufficient biocatalytic cascade for the continuous synthesis of danshensu in flow. Appl Microbiol Biotechnol 109
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Shouquan Zhou and Yan Liu and Fengjiao Ren and Siyu Zhang and Xueying Shi and Bin Wu and Longfei Yan and Jingjing Chen and Fuweng Zhang, Efficient synthesis of LiFSI based on Reaction-Extraction coupling method, Separation and Purification Technology, 2025
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O’Hanlon, Diarmuid and Davin, Sharon and Glennon, Brian and Baumann, Marcus, Metal-free [2+2]-photocycloaddition of unactivated alkenes enabled by continuous flow processing, Chem. Commun. 2025
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Rowley, Bethan M. and Thompson, Lisa A. and Power, Luke A. and Daglish, James and Parks, Emma and Birbeck, James and Marsden, Steve and Kapur, Nikil and Blacker, A. John, Integrating continuous flow reaction and work-up: chiral amine resolution{,} separation and purification using a novel coalescing filter system, React. Chem. Eng. 2025
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Simoens, Andreas and Dejaegere, Andreas and Vandevelde, Marthe and Stevens, Christian V. Continuous flow synthesis of N{,}N-dimethyltryptamine (DMT) analogues with therapeutic potential, RSC Med. Chem. 2025
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Hessel, Volker and Tran, Nam Nghiep and Orandi, Sanaz and Asrami, Mahdieh Razi and Goodsite, Michael and Nguyen, Hung, Continuous-Flow Extraction of Adjacent Metals—A Disruptive Economic Window for In Situ Resource Utilization of Asteroids? Angewandte Chemie International Edition, 2021
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Fang, Zhengqi and Zhou, Jian and Xing, Dong and He, Haibing and Gao, Shuanhu, On-Demand Production of Two Commercial Plant Activators, Tiadinil and Methiadinil, under an Integrated Continuous Flow System, Organic Process Research & Development, 2024
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Rebecca E. Ruscoe and Sebastian C. Cosgrove Future directions in flow biocatalysis: The impact of new technology on sustainability, Current Opinion in Green and Sustainable Chemistry 2024
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Joscha Boehm and Daniel Moser and Peter Neugebauer and Jakob Rehrl and Peter Poechlauer and Dirk Kirschneck and Martin Horn and Martin Steinberger and Stephan Sacher, A modeling and control framework for extraction processes, Chemical Engineering Science, 2024
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Alfano, Antonella Ilenia and Smyth, Megan and Wharry, Scott and Moody, Thomas S. and Nuño, Manuel and Butters, Chris and Baumann, Marcus, Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach Chem. Commun. 2024
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Daglish, James and Blacker, A. John and de Boer, Gregory and Russell, Stephen J. and Tausif, Muhammad and Hose, David R. J. and Parsons, Anna R. and Crampton, Alex and Kapur, Nikil, A Coalescing Filter for Liquid–Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry, Organic Process Research & Development, 2024
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Buttranon, Supacha and Jaroensuk, Juthamas and Chaiyen, Pimchai and Weeranoppanant, Noppho, Integrated Continuous-Flow Production of Wax Esters Combining Whole-Cell and In Vitro Biocatalysis, Organic Process Research & Development, 2024
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Bošković, Dušan and Loebbecke, Stefan and Panić, Slobodan and Piscopo, Calogero and Radulescu, Ligia and Schwarzer, Maud, Diazoacetonitrile: Safe and Green Synthesis through Continuous Processing, Chemie Ingenieur Technik, 2024
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Song, Lei and Ang, Hwee Ting and Senthilperumal, Jagadeesan and Kanusu, Umamaheswara Rao and Venugopal, Sivasankaran and Rangarajan, Naveen and Krishnamoorthy, Shivasankar and Dubbaka, Srinivas Reddy and O’Neill, Patrick and Wu, Jie, 1,2,3-Triazole Synthesis: Development of Safe and Effective Batch and Continuous Manufacturing Processes, Organic Process Research & Development, 2024
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Velichko, Viktoria and Cambie, Dario and Secci, Francesco, Continuous flow oxidation of alkynes with KMnO4 for the synthesis of 1{,}2-diketone derivatives, React. Chem. Eng. 2024
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Phakoukaki, Yiota Victoria; Studies of continuous intensified liquid-liquid extraction of biomolecules using ionic liquids in small channels, 2024
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Jacopo Brucoli, FROM BATCH TO FLOW: RETHINK THE WAY OF DOING CHEMISTRY 2023
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Cavedon, Cristian and Mear, Sarah Jane and Croke, Austin and Jamison, Timothy F, Continuous-flow copper hydride-catalyzed reduction of 2{,}1-benzoisoxazoles, React. Chem. Eng. 2024
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Jacopo Brucoli and Alessandra Puglisi and Sergio Rossi and Davide Gariboldi and Davide Brenna and Ivano Maule and Maurizio Benaglia, A three-minute gram-scale synthesis of amines via ultrafast “on-water” in continuo organolithium addition to imines, Cell Reports Physical Science, 2024
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Jang, Heejeong and Chu, Hyunseon and Noh, Hyojoo and Kim, Kyoung Taek, Shotgun Sequencing of 512-mer Copolyester Allows Random Access to Stored Information, Angewandte Chemie International Edition, 2025
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William G. Whitford, Advances in Sustainable Oligo Manufacturing, 2024
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Silva Elipe, Maria Victoria and Ndukwe, Ikenna Edward and Murray, James I., Cryogen-free 400-MHz nuclear magnetic resonance spectrometer as a versatile tool for pharmaceutical process analytical technology Magnetic Resonance in Chemistry, 2024
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Valotta, Alessia and Stelzer, Daniela and Reiter, Tamara and Kroutil, Wolfgang and Gruber-Woelfler, Heidrun, A multistep (semi)-continuous biocatalytic setup for the production of polycaprolactone, React. Chem. Eng. 2024
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Asano, S., Miyamura, H., Matsushita, M. et al. Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor. J Flow Chem, 2024
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Griwatz, Jan H. and Campi, Chiara E. and Kunz, Anne and Wegner, Hermann A. In-situ Oxidation and Coupling of Anilines towards Unsymmetric Azobenzenes Using Flow Chemistry, ChemSusChem, 2024
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van Wyk, Lorinda T. and Neyt, Nicole C. and Jugmohan, Jaimee and Panayides, Jenny-Lee and Riley, Darren L., The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies, React. Chem. Eng, 2024
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Filipponi, Paolo and Cerra, Bruno and Piccinno, Alessandro and Camaioni, Emidio and Gioiello, Antimo, Continuous Flow Synthesis of the PARP-1/2 Inhibitor HYDAMTIQ: Synthetic Strategy, Optimization, and Green Metrics Evaluation, Organic Process Research & Development, 2024
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Xie, Bingqi and Liu, Wei and Jiang, Yifan and Chen, Junxin and Zhou, Caijin and Zhang, Jisong, Hydrodynamics and model of gas-liquid flow in microbubble column reactors, AIChE Journal, 2024
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Kim, Sohyeon and Suh, Hyena and Park, Boyoung Y. Photo-induced Multiphasic Reactions in Flow Process: A Decade of Progress, Asian Journal of Organic Chemistry, 2023
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Prieschl, Michael, Sulzer, Niklas, Sedelmeier, Joerg, Kaldre, Dainis, Lebl, René, Püntener, Kurt, Hildbrand, Stefan, Williams, Jason D., Kappe, C. Oliver, Leveraging flow chemistry for the synthesis of trisubstituted isoxazoles, Journal of Flow Chemistry, 2023
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Tomohiro Ichitsuka, Masahide Sato, Shiho Miura, Takashi Makino, and Takayuki Ishizaka, Telescoped Two-Step Continuous-Flow Synthesis of Vanillin
ACS Sustainable Chemistry & Engineering 2023
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Nova-Fernández, José Luis, Pascual-Coca, Gustavo, Cabrera, Silvia, Alemán, José, Rapid and Safe Continuous-Flow Simmons-Smith Cyclopropanation using a Zn/Cu Couple Column, Advanced Synthesis & Catalysis, 2024
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Ge, X.; Chen, Y.; Sànchez i Nogué, V.; Li, Y. Volatile Fatty Acid Recovery from Arrested Anaerobic Digestion for the Production of Sustainable Aviation Fuel: A Review. Fermentation 2023
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Andresini, Michael and Colella, Marco and Dibenedetto, Roberta Savina and Graziano, Elena and Romanazzi, Giuseppe and Aramini, Andrea and Degennaro, Leonardo and Luisi, Renzo, Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines, React. Chem. Eng. 2023
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Yusuke Sato, Junliang Liu, Ikenna Edward Ndukwe, Maria Victoria Silva Elipe, Daniel J. Griffin, James I. Murray, Jason E. Hein, Liquid/liquid heterogeneous reaction monitoring: Insights into biphasic Suzuki-Miyaura cross-coupling, Chem Catalysis, 2023
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Viacheslav V. Pendiukh, Hanna V. Yakovleva, Ivan A. Stadniy, Alexander E. Pashenko, Eduard B. Rusanov, Natalia V. Grabovaya, Sergey V. Kolotilov, Alexander B. Rozhenko, Serhiy V. Ryabukhin, and Dmytro M. Volochnyuk, Practical Synthetic Method for Amino Acid-Derived Diazoketones Shelf-Stable Reagents for Organic Synthesis, Organic Process Research & Development 2024
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Chaichol, Patchara and Weeranoppanant, Nopphon, Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification, React. Chem. Eng. 2023
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Arveiler, Maël and Ognier, Stephanie and Venier, Olivier and Schio, Laurent and Tatoulian, Michael, An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures, React. Chem. Eng. 2023
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Kardelen Kaya-Özkiper, Keiran Mc Carogher, Anca Roibu, and Simon Kuhn, Photo-Oxidation in Three-Phase Flow with Continuous Photosensitizer Recycling, ACS Sustainable Chemistry & Engineering 2023
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Sebastian C. Cosgrove, Gavin J. Miller, Amin Bornadel, and Beatriz Dominguez, Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase, ACS Sustainable Chemistry & Engineering 2023
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Katarzyna A. Maltby, Krishna Sharma, Marc A. S. Short, Sannia Farooque, Rosalie Hamill, A. John Blacker, Nikil Kapur, Charlotte E. Willans, and Bao N. Nguyen, Rationalizing and Adapting Water-Accelerated Reactions for Sustainable Flow Organic Processes ACS Sustainable Chemistry & Engineering 2023
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Hato, Yoshio and Jamison, Timothy F. Multi-platform synthesis of ondansetron featuring process intensification in flow, React. Chem. Eng. 2023
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Trapp, S., Lammers, T., Engudar, G. et al. Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop .EJNMMI radiopharm. chem, 2023
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Rojan Ali, Dr. Rasool Babaahmadi, Dr. Matthew Didsbury, Dr. Rebecca Stephens, Prof. Rebecca L. Melen, Prof. Thomas Wirth, Flow Electrochemistry for the N-Nitrosation of Secondary Amines, Chemistry – A European Journal, 2023
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Mandle, R. J. Automated flow synthesis of algorithmically designed ferroelectric nematogens. Liquid Crystals, 2023
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Zhiguo WANG, Hongxia LIU, Zhigang WANG and Xuefeng YANG A CONTINUOUS SYNTHESIS METHOD OF HYDROXYLMETHYL
PHOSPHONATES USING THE MICROFLUIDIC REACTOR, 2023
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Dr. Fanfu Guan, Yu Qian, Peiqi Zhang, Dr. Runtong Zhang, Prof. Xumu Zhang, Dr. Jialin Wen, Fast Isomerization Before Isomerization-Hydroformylation: Probing the Neglected Period with A Novel Microfluidic Device Angewandte Chemie International Edition, 2023
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Michałek, Stanisław and Maj, Anna M. and Gurba-Bryśkiewicz, Lidia and Maruszak, Wioleta and Zagozda, Marcin and Ochal, Zbigniew and Dubiel, Krzysztof and Wieczorek, Maciej, Development and optimization of a continuous flow ester reduction with LiAlH4 in the synthesis of a key intermediate for a PI3Kδ inhibitor (CPL302415), React. Chem. Eng. 2023
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Krstić, M.; Rossi, S.; Sanz, M.; Puglisi, A. Laboratory Scale Continuous Flow Systems for the Enantioselective Phase Transfer Catalytic Synthesis of Quaternary Amino Acids. Molecules 2023
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García-Lacuna, J.; Baumann, Inline purification in continuous flow synthesis – opportunities and challenges M. Beilstein J. Org. Chem. 2022
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Lars-Erik Meyer, Markus Hobisch, Selin Kara, Process intensification in continuous flow biocatalysis by up and downstream processing strategies, Current Opinion in Biotechnology, 2022
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Stephen P. Lathrop, Laurie B. Mlinar, Onkar N. Manjrekar, Yong Zhou, Kaid C. Harper, Eric R. Sacia, Molly Higgins, Andrew R. Bogdan, Zhe Wang, Steven M. Richter, Wei Gong, Eric A. Voight, Jeremy Henle, Moiz Diwan, Jeffrey M. Kallemeyn, Jack C. Sharland, Bo Wei, and Huw M. L. Davies, Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation, Organic Process Research & Development, 2023
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Willem Vereycken, Joren van Stee, Sofía Riaño, Tom Van Gerven, Koen Binnemans, Effect of dilution on the performance of ionic liquids in milliflow solvent extraction applications: Towards integration of extraction, scrubbing and stripping operations with in-line membrane-based phase separation , Separation and Purification Technology, Sep 2022
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Stephan Sacher, Ismael Castillo, Jakob Rehrl, Peter Sagmeister, René Lebl, Julia Kruisz, Selma Celikovic, Martin Sipek, Jason D. Williams, Dirk Kirschneck, C. Oliver Kappe, and Martin Horn, Automated and continuous synthesis of drug substances, Chemical Engineering Research and Design, Jan 2022.
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Yiota-Victoria Phakoukaki, Paul O’Shaughnessy, Panagiota Angeli, Intensified liquid-liquid
extraction of biomolecules using ionic liquids in small channels, Separation and Purification and Technology, Feb 2022.
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David Roura Padrosa and Martina L. Contente, Multi-gram preparation of
cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process,
Tetrahedron Letters, Dec 2021.
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Cecilia Pinna, Piera Anna Martino, Gabriele Meroni, Valerio Massimo Sora, Lucia Tamborini, Sabrina
Dallavalle, Martina L. Contente, and Andrea Pinto, Biocatalyzed Synthesis of Vanillamides and
Evaluation of Their Antimicrobial Activity, J. Agric. Food Chem., Dec 2021.
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Francesca Annunziata, Alessandra Guaglio, Paola Conti, Lucia Tamborini and Raffaella Gandolfi, Continuous-flow
stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic
solvents, Green Chemistry, Dec 2021.
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Mara Di Filippo and Marcus Baumann, Continuous Flow
Synthesis of Anticancer Drugs, Molecules, Nov 2021.
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Francesca Annunziata, Martina L. Contente, Cecilia Pinna, Lucia Tamborini, and Andrea Pinto, Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and
Efficient Production of Their Acetate Esters, Antioxidants, July 2021.
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Jinu Joseph John, Tom Van Gerven, Effect of ultrasound on
parallel flow in a microchannel, Chemical Engineering and Processing – Process
Intensification, May 2021.
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Itziar Peñafiel, Sebastian C. Cosgrove, Biocatalysis in Flow for Drug Discovery,
Flow Chemistry in Drug Discovery, April 2021.
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Dimitrios Tsaoulidis, Milan Mamtora, Miguel Pineda, Eric S.Fraga, and Panagiota Angeli, Experimental and CFD
scale-up studies for intensified actinide/lanthanide separations, Chemical Engineering and
Processing – Process Intensification, Mar 2021.
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Jorge García-Lacuna, Tobias Fleiß, Rachel Munday, Kevin Leslie, Anne O’Kearney-McMullan, Christopher A. Hone, and C.
Oliver Kappe, Synthesis of the Lipophilic
Amine Tail of Abediterol Enabled by Multiphase Flow Transformations, Org. Process
Res. Dev., Mar 2021.
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Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphaël Robiette,
and Jean-Christophe M. Monbaliu, A modular, low footprint
and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones,
Green Chemistry, Feb 2021.
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Micol Santi, Luca Sancineto, Vanessa Nascimento, Juliano Braun Azeredo, Erika V. M. Orozco, Leandro H. Andrade,
Harald Gröger, and Claudio Santi, Flow Biocatalysis: A
Challenging Alternative for the Synthesis of APIs and Natural Compounds, International Journal of
Molecular Sciences, Jan 2021.
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Mellisa B. Sagandira, Cloudius R. Sagandira, and Paul Watts, Continuous flow synthesis of xylidines
via biphasic nitration of xylenes and nitro-reduction, Journal of Flow Chemistry, Jan 2021.
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Glen Surjadinata, Luke Hunter, Lidia Matesic, and Giancarlo Pascali, Analytical-scale synthesis of
aryl-SF4Cl via flow microfluidic technology, Journal of Flow Chemistry., Jan 2021.
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Samuel J. Miller, Haruro Ishitani, Yuichi Furiya, and Shu̅ Kobayashi, High-Throughput Synthesis of
(S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions, Org. Process Res.
Dev., Jan 2021.
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Jillian W. Sheeran, Kiersten Campbell, Christopher P. Breen, Gerald Hummel, Changfeng Huang, Anamika Datta, Serge H.
Boyer, Scott J. Hecker, Matthew M. Bio, Yuan-Qing Fang, David D. Ford, and M. Grace Russell, Scalable On-Demand Production of Purified
Diazomethane Suitable for Sensitive Catalytic Reactions, Org. Process Res. Dev., Jan 2021.
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Dimitrios Tsaoulidis, Milan Mamtora, Marta Mayals Gañet,
Eduardo Garciadiego-Ortega, and Panagiota Angeli,
Scale-Up Studies for Co/Ni Separations in Intensified Reactors, Micromachines., Dec 2020.
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Hoang Khang Bui, Ki Yoon Kim, Hyeonjin Kim, Jae‐Pyoung Ahn, Taekyung Yu, and Tae Seok Seo, Total Integration of the Sample
Injection, Microdroplet Reaction, Phase Separation, Real‐Time Optical Detection, and Recovery of Diverse
Silver–Gold Bimetallic Nanoalloys in a Continuous Process,Particle., Dec 2020.
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Su Wang, Yeersen Patehebieke, Zheng Zhou, Zhibing Zhang, and Xiao Wang, Recent
Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous
Catalysts,Catalysts, Nov 2020.
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Piera De Santis, Lars-Erik Meyer, and Selin Kara, The rise of continuous flow
biocatalysis – fundamentals, very recent developments and future perspectives, Reaction Engineering
and Chemistry, Oct 2020.
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Naoto Sugisawa, Hiroyuki Nakamura, and Shinichiro Fuse, Catalyst-free biphasic oxidation of
Thiophenes in continuous-flow, Journal of Flow Chemistry, Jul 2020.
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Jorge García‐Lacuna, Prof. Dr. Gema Domínguez, and Prof. Dr. Javier Pérez‐Castells, Flow Chemistry for
Cycloaddition Reactions, ChemSusChem, Jul 2020.
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Elizabeth Farrant Automation of
Synthesis in Medicinal Chemistry: Progress and Challenges, ACS Med. Chem. Lett., Jul 2020.
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Alejandro Mata, Ulrich Weigl, Oliver Flögel, Pius Baur, Christopher A. Hone and C. Oliver Kappe, Acyl azide generation and amide bond
formation in continuous-flow for the synthesis of peptides, React. Chem. & Eng., Mar 2020.
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Kristina Søborg Pedersen, Christina Baun, Karin Michaelsen Nielsen, Helge Thisgaard, Andreas Ingemann Jensen and
Fedor Zhuravlev, Design,
Synthesis, Computational, and Preclinical Evaluation of natTi/45Ti-Labeled Urea-Based Glutamate PSMA
Ligand, Molecules, Mar 2020.
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Peter Sagmeister, Johannes Poms, Jason Williams and C. Oliver Kappe, Multivariate analysis
of inline benchtop NMR data enables rapid optimization of a complex nitration in flow, React. Chem.
& Eng., Feb 2020.
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Adam D. Clayton, Luke A. Power, William R. Reynolds, Caroline Ainsworth, David R. J. Hose, Martin F. Jones, Thomas
W. Chamberlain, A. John Blacker & Richard A. Bourne, Self-optimising reactive extractions:
towards the efficient development of multi-step continuous flow processes, Journal of Flow
Chemistry, Feb 2020.
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Victor-Emmanuel H. Kassin, Thomas Toupy, Guillaume Petit, Pauline Bianchi, Elena Salvadeo & Jean-Christophe M.
Monbaliu, Metal-free hydroxylation
of tertiary ketones under intensified and scalable continuous flow conditions, Journal of Flow
Chemistry, Feb 2020.
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Chetsada Khositanon, Kanyaporn Adpakpang, Sareeya Bureekaew & Nopphon Weeranoppanant, Continuous-flow purification of silver
nanoparticles and its integration with flow synthesis, Journal of Flow Chemistry, Feb
2020.
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Govaerts, S., Nyuchev, A. & Noel, T., Pushing the
boundaries of C–H bond functionalization chemistry using flow technology, J Flow Chem,
Feb 2020.
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Antimo Gioiello, Alessandro Piccinno, Anna Maria Lozza, and Bruno Cerra, The Medicinal Chemistry in the Era of Machines
and Automation: Recent Advances in Continuous Flow Technology, Journal of Medicinal
Chemistry, Feb 2020.
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V Volker Hessel, Nam Nghiep Tran, Sanaz Orandi, Mahdieh Razi Asrami, Michael Evan Goodsite, Hung T. Nguyen,
Continuous-Flow Extraction of
Adjacent Metals – a Disruptive Economic Window for In-Situ Resource Utilization of Asteroids?,
Angewandte Chemie, Jan 2020.
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Francesca Tentori, Elisabetta Brenna, Michele Crotti, Giuseppe Pedrocchi‐Fantoni, Maria Chiara Ghezzi and Davide
Tessaro, Continuous‐Flow
Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather
Cyclohexanol (4‐Isopropylcyclohexanol) and Woody Acetate (4‐(Tert‐Butyl)Cyclohexyl Acetate),
Catalysts, Jan 2020.
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Edith Chow, Burkhard Raguse, Enrico Della Gasper, Steven J. Barrow, Jungmi Hong, Lee J. Hubble, Roger Chai, James S.
Cooper and Andrea Sosa Pintos, Flow-controlled
synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation, React.
Chem.Eng., Jan 2020.
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Nopphon Weeranoppanant and Andrea Adamo, In-Line Purification: A Key Component to
Facilitate Drug Synthesis and Process Development in Medicinal Chemistry, ACS Med. Chem.
Lett., Dec 2019.
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Adam D. Clayton, Artur M.Schweidtmann, Graeme Clemens, Jamie A. Manson, Connor J.Taylor, Carlos G.Niñod Thomas
W.Chamberlain, Nikil Kapur, A. John Blacker, Alexei A.Lapkin, Richard A.Bourne, Automated self-optimisation of
multi-step reaction and separation processes using machine learning, Chemical Engineering
Journal, Nov 2019.
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Le Sang, Jiacheng Tu, Han Cheng, Guangsheng Luo, Jisong Zhang, Hydrodynamics and mass transfer of
gas–liquid flow in micropacked bed reactors with metal foam packing, AIChE Journal,
Sep 2019.
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Martina Letizia Contente Francesca Paradisi, Transaminase‐catalyzed continuous
synthesis of biogenic aldehydes, ChemBioChem, June 2019.
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Martina Letizia Contente, Stefano Farris, Lucia Tamborini, Francesco Molinari, and Francesca Paradisi, Flow-based enzymatic synthesis of
melatonin and other high value tryptamine derivatives: a five-minute intensified process, Green
Chem., May 2019.
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Luke Rogers and Klavs F. Jensen, Continuous manufacturing – the Green
Chemistry promise?, Green Chem., May 2019.
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Zinia Jaman, Tiago J. P. Sobreira, Ahmed Mufti, Christina R. Ferreira, R. Graham Cooks, and David H. Thompson,
Rapid On-Demand Synthesis of Lomustine under
Continuous Flow Conditionss, Org. Process Res. Dev., Feb 2019.
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René Lebl, David Cantillo, and C. Oliver Kappe, Continuous generation, in-line
quantification and utilization of nitrosyl chloride in photonitrosation reactions, React. Chem.
Eng., Jan 2019.
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Matthew P. Thompson, Itziar Peñafiel, Sebastian C. Cosgrove, and Nicholas J. Turner, Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals, Organic Process Research and
Development, Jan 2019.
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Petra Martini, Andrea Adamo, Neilesh Syna, Alessandra Boschi, Licia Uccelli, Nopphon Weeranoppanant, Jack Markham,
and Giancarlo Pascali, Perspectives on the Use of Liquid Extraction for Radioisotope Purification, Molecules, Jan 2019.
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Jenny-Lee Panayides, Darren Lyall Riley, Rachel Chikwamba and Ian Strydom, Landscape and
opportunities for active pharmaceutical ingredient manufacturing in developing African economies,
Reaction Chemistry and Engineering, Jan 2019.
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Samir Diab, Nikolaos Mytis, Andreas G.Boudouvis, and Dimitrios I.Gerogiorgis, Process Modelling, Design and
Technoeconomic Liquid-Liquid Extraction (LLE) Optimisation for Comparative Evaluation of Batch vs.
Continuous Pharmaceutical Manufacturing of Atropine,, Computers and Chemical
Engineering, Dec 2018.
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Dr. Mathieu Lesieur, Dr. Claudio Battilocchio, Dr. Ricardo Labes, Dr. Jérôme Jac,q Dr. Christophe Genicot, Prof.
Steven V. Ley, and Dr. Patrick Pasau, Direct Oxidation of Csp3−H bonds using
in Situ Generated Trifluoromethylated Dioxirane in Flow, Chemistry, Nov 2018.
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Clément Audubert, Alexanne Bouchard, Gary Mathieu, and Hélène Lebel, Chemoselective Synthesis of Amines from Ammonium
Hydroxide and Hydroxylamine in Continuous Flow, The Journal of Organic Chemistry, Oct
2018.
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Kristina Søborg Pedersen, Joseph Imbrogno, Jesper Fonslet, Marcella Lusardi, Klavs F. Jensen and Fedor Zhuravlev,
Liquid–liquid
extraction in flow of the radioisotope titanium-45 for positron emission tomography applications,
Reaction Chemistry and Engineering, Oct 2018.
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Anne-Catherine Bédard, Andrea Adamo, Kosi C. Aroh, M. Grace Russell, Aaron A. Bedermann, Jeremy Torosian, Brian Yue,
Klavs F. Jensen, and Timothy F. Jamison, Reconfigurable system for automated optimization
of diverse chemical reactions, Science, Sep 2018.
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Carlos Mendoza Noémie Emmanuel Carlos Paez Laurent Dreesen Jean-Christophe M. Monbaliu, and Benoît Heinrichs,
Improving Continuous Flow Singlet
Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles
ChemPhotoChem Aug 2018.
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Eric Yu, Hari P R Mangunuru, Nakul S Telang, Caleb J Kong, Jenson Verghese, Stanley E Gilliland III, Saeed Ahmad,
Raymond N Dominey, and B Frank Gupton, High-yielding
continuous-flow synthesis of antimalarial drug hydroxychloroquine, Beilstein J Org
Chem. March 2018.
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Hongwei Yang, Benjamin Martin, and Berthold Schenkel, On-Demand Generation and Consumption of
Diazomethane in Multistep Continuous Flow Systems, Organic Process Research &
Development March 2018.
–
Koichiro Masuda, Tomhohiro Ichitsuka, Nagatoshi Koumura, Kazuhito Sato, Shu Kobayashi, Flow fine synthesis with
heterogeneous catalysts, Tetrahedron Feb 2018.
–
Gemoets, H. P. L. (2018). Enabling and
accelerating C-H functionalization through continuous-flow chemistry Eindhoven: Technische Universiteit
Eindhoven
–
Jatuporn Salaklang, Veronique Maes, Matthias Conradi, Rudy Damsb and Tanja Junkers, Direct synthesis of
acrylate monomers in heterogeneous continuous flow processes Reaction Chemistry and
Engineering Dec 2017.
–
Joshua Britton and Timothy F Jamison, The assembly
and
use of continuous flow systems for chemical synthesis Nature Protocols Oct 2017.
–
Dr. Martina L. Contente, Federica Dall’Oglio, Dr. Lucia Tamborini, Prof. Francesco Molinari, Prof. Francesca
Paradisi, Highly Efficient Oxidation of Amines to Aldehydes with Flow-based
Biocatalysis
ChemCatChem Sep 2017.
–
Gabriel Glotz, Rene Lebl, Doris Dallinger, C. Oliver Kappe, Integration of Bromine and Cyanogen Bromide Generators for the Telescoped Continuous
Synthesis of Cyclic Guanidines Angew. Chem. Int. Ed. Sep 2017.
–
Amanda C. Wicker, Frank A. Leibfarth and Timothy F. Jamison, Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular
macromolecules Polym. Chem. Sep 2017.
–
Valerio De Vitis, Federica Dall’Oglio, Andrea Pinto, Carlo De Micheli, Francesco Molinari, Paola Conti, Diego
Romano, Lucia Tamborini, Chemoenzymatic Synthesis in Flow
Reactors: A Rapid and Convenient Preparation of Captopril, Chemistry Open July 2017.
–
Michael R Chapman, Maria H. Kwan, Georgina King, Katherine E Jolley, Mariam Hussain, Shahed Hussain, Ibrahim E
Salama, Carlos González Nino, Lisa A Thompson, Mary E Bayana, Adam Clayton, Bao N. Nguyen, Nicholas J Turner, Nikil
Kapur, and
A. John Blacker, A Simple and Versatile
Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times Org.
Process Res. Dev. June 2017.
–
Jinu Joseph John, SimonKuhn, Leen Braeken, and Tom Van Gerven, Temperature controlled interval
contact design for ultrasound assisted liquid-liquid extraction Chem. Eng. Res. Des.
June
2017.
–
Hannes P. L. Gemoets, Gabriele Laudadio, Kirsten Verstraete, Prof. Dr. Volker Hessel, and Dr. Timothy Noël,
A Modular Flow Design for the
meta-Selective C−H Arylation of Anilines Angew. Chem. Int. Ed. May 2017.
–
Nopphon Weeranoppanant, Andrea Adamo, Galym Saparbaiuly, Eleanor Rose, Christian Fleury, Berthold Schenkel, and
Klavs F. Jensen, Design of Multistage Counter-Current Liquid–Liquid Extraction for Small-Scale
Applications Ind. Eng. Chem. Res. Apr 2017.
–
Yi Shen, Nopphon Weeranoppanant, Lisi Xie, Yue Chen, Marcella R. Lusardi, Joseph Imbrogno, Moungi G. Bawendi and
Klavs F. Jensen, Multistage extraction platform for highly efficient and fully continuous
purification of nanoparticles Nanoscale Mar 2017.
–
C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S. V. Ley Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and
ethylene gas React. Chem. Eng. Mar 2017.
–
Joshua Britton and Colin L. Raston, Multi-step continuous-flow synthesis Chem. Soc. Rev. Jan 2017.
–
David Cantillo, Bernd Wolf, Roland Goetz, and C. Oliver Kappe, Continuous Flow
Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization
Sequence Org. Process Res. Dev. Dec 2016.
–
Hansjoerg Lehmann, A scalable and safe continuous flow procedure for in-line generation of
diazomethane and its precursor MNU. Green Chemistry. Dec 2016.
–
Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and
extraction Org. Process Res. Dev. Aug 2016.
–
Franz J. Strauss, David Cantillo, Javier Guerrac and C. Oliver Kappe, A laboratory-scale continuous flow chlorine generator for organic synthesis
React. Chem. Eng. Aug 2016.
–
Baptiste Leforestiera and Markus Vögtle, Safe Generation and Direct Use of Chlorine Azide in Flow Chemistry: 1,2-Azidochlorination of
Olefins and Access to Triazoles Synlett. June 2016.
–
Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam, Jie Chen, Timothy F. Jamison, Klavs F. Jensen, Jean-Christophe
M. Monbaliu, Allan S. Myerson, Eve M. Revalor, David R. Snead, Torsten Stelzer, Nopphon Weeranoppanant, Shin Yee
Wong, Ping Zhang, On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable
system
Science April 2016.
–
L Osorio-Planes, C Rodríguez-Escrich, MA Pericas, Removing the superfluous: a supported squaramide catalyst with a minimalistic linker
applied to the enantioselective flow synthesis of pyranonaphthoquinones Catalysis
Science & Technology Mar 2016.
–
Lorenzo Di Marco, Dr. Morgan Hans, Prof. Lionel Delaude and Dr. Jean-Christophe M. Monbaliu, Continuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Chem. Eur. J. Feb 2016.
–
Javier Guerra, David Cantillo and C Oliver Kappe, Visible-Light Photoredox Catalysis using a Macromolecular Ruthenium Complex: Reactivity
and Recovery by Size-Exclusion Nanofiltration in Continuous Flow Catal. Sci.
Technol. Feb 2016.
–
Nicolas Lamborelle, Justine F Simon, Andre LUXEN and Jean-Christophe Monbaliu, Continuous-Flow Thermolysis for the Preparation of Vinylglycine Derivatives
Org. Biomol. Chem. Nov 2015.
–
Irina Sagamanova, Carles Rodríguez-Escrich, István Gábor Molnár, Sonia Sayalero, Ryan Gilmour, and Miquel A.
Pericàs, Translating the Enantioselective Michael Reaction to a Continuous Flow Paradigm with an
Immobilized, Fluorinated Organocatalyst ACS Catal. Sept 2015.
–
Leibfarth FA, Johnson JA, and Jamison TF, Scalable synthesis of sequence-defined, unimolecular macromolecules by
Flow-IEG
Proc. Natl. Acad. Sci. Aug 2015.
–
Chunhui Dai, David R. Snead, Ping Zhang, and Timothy F. Jamison, Continuous-Flow Syn and Purification of
Atropine with Sequential In-Line Separations of Structurally Similar Impurities J.
Flow Chem. July 2015.
–
Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio and Steven V.
Ley,
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under
flow conditions Org. Biomol. Mol. Oct 2014.
–
Trevor A. Hamlin, Gillian M. L. Lazarus, Christopher B. Kelly, and Nicholas E. Leadbeater, A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes:
Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent
Switching. Org. Process Res. Dev. Aug 2014.
–
Andrea Adamo, Patrick L Heider, Nopphon Weeranoppanant, and Klavs F. Jensen, Membrane-Based, Liquid-Liquid Separator with Integrated
Pressure Control. Ind. Eng. Chem. Res. July 2013.
–
Gas-Liquid Separation
Gas-Liquid Separation
Asano, S., Miyamura, H., Matsushita, M. et al. Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor. J Flow Chem, 2024
–
Xie, Bingqi and Liu, Wei and Jiang, Yifan and Chen, Junxin and Zhou, Caijin and Zhang, Jisong, Hydrodynamics and model of gas-liquid flow in microbubble column reactors, AIChE Journal, 2024
–
Leung, G.Y.C., Ying, S.T.R., Chia, E. et al. Safe and on-demand protocol for the continuous generation of SO2 and Cl2 for subsequent utilization in organic synthesis. J Flow Chem 2024
–
Sheeran, Jillian W. and Campbell, Kiersten and Breen, Christopher P. and Hummel, Gerald and Huang, Changfeng and Datta, Anamika and Boyer, Serge H. and Hecker, Scott J. and Bio, Matthew M. and Fang, Yuan-Qing and Ford, David D. and Russell, M. Grace, Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions, Organic Process Research & Development, 2021
–
Guan, Fanfu and Kapur, Nikil and Sim, Louise and Taylor, Connor J. and Wen, Jialin and Zhang, Xumu and Blacker, A. John, A universal reactor platform for batch and flow: application to homogeneous and heterogeneous hydrogenation, React. Chem. Eng. 2020
–
Jisong Zhang, Andrew R. Teixeira, Lars Thilo Kögl, Lu Yang, and Klavs F. Jensen Hydrodynamics of gas–liquid flow in
micropacked beds: Pressure drop, liquid holdup, and two-phase model AIChE
Journal June 2017.
–
Everett J. O’Neal, Chang Ho Lee, Julian Brathwaite, and Klavs F. Jensen, Continuous Nanofiltration and Recycle of an
Asymmetric Ketone Hydrogenation Catalyst ACS Catal. March 2015.
–
Reference to separator’s theory:
Kralj, J. G.; Sahoo, H. R.; Jensen, K. F., Integrated continuous microfluidic liquid-liquid extraction.
Lab Chip.2007, 7, (2), 256-263.
–
Reference to examples of use of liquid–liquid separators:
Sahoo, H. R.; Kralj, J. G.; Jensen, K. F., Multistep Continuous-Flow Microchemical Synthesis Involving Multiple
Reactions and Separations. Angew. Chem. Int. Ed. 2007, 46, (30), 5704-5708.
–
Cervera-Padrell, A. E.; Morthensen, S. T.; Lewandowski, D. J.; Skovby, T.; Kiil, S.; Gernaey, K. V., Continuous
Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale
Hydrophobic Membrane Separator. Org. Process Res. Dev. 2012, 16, (5), 888-900.
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Multistage Extraction
Dejaegere, Andreas and Napoli, Alessandro and Heugebaert, Thomas S.A. and Stevens, Christian V., Continuous Dihydrolevoglucosenone Recovery Using Commercial Membrane Technology, Organic Process Research & Development, 2025
–
Murbach, Giulia and Akturk, Ilke and Nagy, Zoltan and Thompson, David H., Process Development and Kinetic Analysis in the Green Synthesis of Lomustine, Organic Process Research & Development
–
Viano, Robert and Milani, Lorenzo and Orkenyi, Robert and Adamo, Andrea, Continuous Separation and Purification of Chemical Species by Continuous Liquid–Liquid Partition Chromatography Implemented with Membrane-Based Phase Separators, Organic Process Research & Development, 2023
–
Cao, Liming and Sun, Maolin and Liang, Chaoming and Yang, Lei and Ma, Yueyue and Cheng, Ruihua and Ke, Yanxiong and Yu, Wei and Ye, Jinxing, A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate, Chinese Chemical Letters, 2023
–
J. Aguirre Solano and Sanja Mišković, Process intensification of metal solvent extraction studies using a miniaturized solvent extraction plant, Chemical Engineering and Processing – Process Intensification, 2024
–
Vasilev, Maksim and Gangu, Aravind S. and Gajula, Praveen and Kaetzel, Nathaniel D. and Natarajan, Vasudevan and Desai, Bimbisar and Sirasani, Gopal and Qu, Bo and Senanayake, Chris H., Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs, Organic Process Research & Development, 2024
–
García-Lacuna, J.; Baumann, Inline purification in continuous flow synthesis – opportunities and challenges M. Beilstein J. Org. Chem. 2022
–
C. Heiduk, I. Hohlen, and S. Scholl, Multi-Stage Liquid/Liquid Extraction with a Zaiput Apparatus, SPhERe – 4rd International Symposium on Pharmaceutical Engineering Research, 15. – 17. Sept 2021.
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Nopphon Weeranoppanant and Andrea Adamo, In-Line Purification: A Key Component to
Facilitate Drug Synthesis and Process Development in Medicinal Chemistry, ACS Med. Chem.
Lett., Dec 2019.
–
René Lebl, Trevor Murray, Andrea Adamo, David Cantillo, C. Oliver Kappe, Continuous Flow
Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid
Extraction and Membrane Separation Technology, ACS Sustainable Chem. Eng., Nov 2019.
–
Scientific research articles relating to our multistage extraction platform:
Nopphon Weeranoppanant, Andrea Adamo, Galym Saparbaiuly, Eleanor Rose, Christian Fleury, Berthold Schenkel, and Klavs F.
Jensen, Design of
Multistage Counter-Current Liquid–Liquid Extraction for Small-Scale Applications Ind. Eng. Chem.
Res. Apr 2017.
–
Yi Shen, Nopphon Weeranoppanant, Lisi Xie, Yue Chen, Marcella R. Lusardi, Joseph Imbrogno, Moungi G. Bawendi and Klavs
F. Jensen, Multistage extraction platform for highly efficient and fully continuous
purification of nanoparticles Nanoscale Mar 2017.
–
Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and extraction
Org. Process Res. Dev. Aug 2016.
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Crystallization
Scientific articles featuring our crystallizer:
G. Aprile, A. V. Pandit, J. Albertazzi, T. Vetter, R. Viano, L. Milani, A. Adamo, A. S. Myerson, T. Stelzer, Residence Time Distribution Characterization and Proof of Concept of a Novel Stacked 7 Stage Continuous Crystallizer Cascade with Diaphragm Driven Slurry Transfer, Ind. Eng. Chem. Res. 2024, 63 (42), 18199–18211
Pressure Regulation
Scientific articles featuring our back pressure regulators:
Lee, Tsz Chun and Tong, Yi and Fu, Wai Chung, Advances in Continuous Flow Fluorination Reactions, Chemistry – An Asian Journal, 2025
–
Wen-Ching Chen and Pin-De Lee and Can-Hong Ni and Ya-Hui Chuang and Guan-Yu Lu and Jia-Lin Zhan and Siu Chun Wong and Ya-Yu Chiang, Flowing to purity: Advancing acetylsalicylic acid production from batch to continuous to full-flow, Separation and Purification Technology, 2025
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Rajendran, Sri Hari Anandhi and Kogler, Sabrina and Kogl, Philipp and Braje, Wilfried M. and Otvos, Sándor B. and Kappe, C. Oliver, Sustainable and Scalable Amidations in Water Using Continuous Slurry-Flow Technology, ACS Sustainable Chemistry & Engineering, 2025
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Moroni, Giada and Tsai, Yi-Hsuan and Ballarotto, Marco and Carotti, Andrea and Monbaliu, Jean-Christophe M. and Gioiello, Antimo, Photooxygenation Reactions of Olefins Under Flow Conditions: An Experimental and In-Silico Study, ChemPhotoChem, 2025
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Sulzer, N., Pusca, E., Pfnier, J. et al. Process intensification toward galanthamine: continuous flow N-methylation of demethylbromonarwedine. J Flow Chem, 2025
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Esneu, AS., Ahmed, P., Pilla, G. et al. Quantitative Investigation of Colloidal Flow and Clogging Kinetics in Porous Medium Using Laser-Induced Fluorescence. Transp Porous Med, 2025
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Yanjiao Xu and Mengbo Zhang and Hengyu Zhong and Shuying Xie and Xuxin Zhu and Haomiao Zhang and Jingdai Wang and Yongrong Yang, Advanced stackable membrane microreactor for gas–liquid-solid reactions: Design, operation, and scale-up, Chemical Engineering Journal, 2025
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Florit, Federico and Nandiwale, Kakasaheb Y. and Armstrong, Cameron T. and Grohowalski, Katharina and Diaz, Angel R. and Mustakis, Jason and Guinness, Steven M. and Jensen, Klavs F., Dynamic flow experiments for Bayesian optimization of a single process objective, React. Chem. Eng. 2025
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Molins, Maite and Fernandez-Garcia, Javier and Berzosa, Xavier, A Tribute to Ullmann’s Work: Expanding Copper Coil Reactor Applications toward the Hydroxylation of Aryl Bromides, Organic Process Research & Development, 2024
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Stefan Desimpel and Jan Dijkmans and Koen P.L. Kuijpers and Matthieu Dorbec and Kevin M. {Van Geem} and Christian V. Stevens, Efficient multi-objective Bayesian optimization of gas–liquid photochemical reactions using an automated flow platform, Chemical Engineering Journal, 2024
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Pandey, Rajat and Akwi, Faith and Watts, Paul, Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine, Organic Process Research & Development, 2024
–
Moroni G, Tsai Y-H, Ballarotto M, Carotti A, Monbaliu J-CM, Gioiello A. Photooxygenation reactions under flow conditions: An experimental and in-silico study. ChemRxiv. 2024
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Silva-Brenes, Diana V. and Agrawal, Shailesh and López-Mejías, Vilmalí and Duconge, Jorge and Vlaar, Cornelis P. and Monbaliu, Jean-Christophe M. and Stelzer, Torsten, Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing, React. Chem. Eng. 2024
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Armstrong, Cameron T. and Grohowalski, Katharina and Russell, Grace and Mason, Sara and Nandiwale, Kakasaheb Y. and Edwards, DaQuawn and Sheeran, Jillian and Steiman, Talia J. and Critcher, Douglas J. and Ashcroft, Christopher P. and Diaz, Angel R. and Guinness, Steven M., Early-Stage Flow Process Development of a Key Intermediate toward PF-07265807, an AXL-MER Inhibitor Oncology Candidate, Organic Process Research & Development, 2024
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Vandekerckhove, Bavo and Van Coillie, Lise and Metten, Bert and Heugebaert, Thomas S. A. and Stevens, Christian V., Development of a solid-compatible continuous flow reactor for the paraformaldehyde slurry mediated α-hydroxymethylation of methyl vinyl ketone, React. Chem. Eng. 2024
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Hayes, Hannah L. D. and Mallia, Carl J., Continuous Flow Chemistry with Solids: A Review, Organic Process Research & Development, 2024
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Sulzer, Niklas and Polterauer, Dominik and Hone, Christopher A. and Kappe, C. Oliver, Preparation of Sulfonyl Chlorides by Oxidative Chlorination of Thiols and Disulfides using HNO3/HCl/O2 in a Flow Reactor, ChemSusChem, 2024
–
Michael R. Dyer and Zhenghan Jing and Kathleen Duncan and Jacqueline Godbe and Monica Shokeen, Advancements in the development of radiopharmaceuticals for nuclear medicine applications in the treatment of bone metastases, Nuclear Medicine and Biology, 2024
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Silva-Brenes, Diana V. and Reyes-Vargas, Stephanie K. and Duconge, Jorge and Vlaar, Cornelis and Stelzer, Torsten and Monbaliu, Jean-Christophe M., Continuous Flow Intensification for the Synthesis of High-Purity Warfarin, Organic Process Research & Development, 2024
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Baldan, Marco and Blauth, Sebastian and Bošković, Dušan and Leithäuser, Christian and Mendl, Alexander and Radulescu, Ligia and Schwarzer, Maud and Wegner, Heinrich and Bortz, Michael, Continuous Synthesis of Diazo Acetonitrile: From Experiments to Physical and Grey-Box Modeling, Chemie Ingenieur Technik, 2024
–
Nova-Fernández, José Luis, Pascual-Coca, Gustavo, Cabrera, Silvia, Alemán, José, Rapid and Safe Continuous-Flow Simmons-Smith Cyclopropanation using a Zn/Cu Couple Column, Advanced Synthesis & Catalysis, 2024
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Maestro, Aitor and Nagy, Bence S. and Otvos, Sándor B. and Kappe, C. Oliver, A Telescoped Continuous Flow Enantioselective Process for Accessing Intermediates of 1-Aryl-1,3-diols as Chiral Building Blocks, The Journal of Organic Chemistry, 2023
–
Nqeketo, Sinazo and Watts, Paul, Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry,The Journal of Organic Chemistry, 2023
–
Cao, Liming and Sun, Maolin and Liang, Chaoming and Yang, Lei and Ma, Yueyue and Cheng, Ruihua and Ke, Yanxiong and Yu, Wei and Ye, Jinxing, A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate, Chinese Chemical Letters, 2023
–
Sagmeister, Peter and Schiller, Christine and Weiss, Peter and Silber, Klara and Knoll, Sebastian and Horn, Martin and Hone, Christopher A. and Williams, Jason D. and Kappe, C. Oliver, Accelerating reaction modeling using dynamic flow experiments{,} part 1: design space exploration, React. Chem. Eng. 2023
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Kardelen Kaya-Özkiper, Keiran Mc Carogher, Anca Roibu, and Simon Kuhn, Photo-Oxidation in Three-Phase Flow with Continuous Photosensitizer Recycling, ACS Sustainable Chemistry & Engineering 2023
–
Venezia, Baldassarre and Gavriilidis, Asterios, Aerobic oxidation of alcohols using a slurry loop membrane reactor,. Green Chem. 2023
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Liu, Hongxia and Wang, Zhiguo, Treatment and resource utilization for a non-biodegradable organophosphorus wastewater using micro-channel reactor, Engenharia Sanitaria e Ambiental, 2023
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Molnár, Márk and Kappe, C. Oliver and Ötvös, Sándor B., Merger of Visible Light-Driven Chiral Organocatalysis and Continuous Flow Chemistry: An Accelerated and Scalable Access into Enantioselective α-Alkylation of Aldehydes, Advanced Synthesis & Catalysis, 2023
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Georgios Gkogkos and Luca Panariello and Eleni Grammenou and Mabel A. Cornwell and Amir Afrashtehpour and Alexander J. MacRobert and Ivan P. Parkin and Asterios Gavriilidis Synthesis of PEG-PPG-PEG templated polydopamine nanoparticles under intensified conditions: Kinetics investigation, continuous process design and demonstration for photothermal application, Chemical Engineering Journal, 2023
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Likit-anurak, Kris and Karki, Ishwor and Howard, Ben I. and Murdock, Laura and Mukhin, Nikolai and Brannon, Jamie and Hepstall, Aubrey and Young, Bridgett and Shimpalee, Sirivatch and Benicewicz, Brian and Meekins, Benjamin, Polybenzimidazole Membranes as Nafion Replacement in Aqueous HCl Electrolyzers, ACS Applied Energy Materials, 2023
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Zhiguo WANG, Hongxia LIU, Zhigang WANG and Xuefeng YANG A CONTINUOUS SYNTHESIS METHOD OF HYDROXYLMETHYL PHOSPHONATES USING THE MICROFLUIDIC REACTOR, 2023
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Campalani, Carlotta and Petit, Guillaume and Monbaliu, Jean-Christophe M. and Selva, Maurizio and Perosa, Alvise, Continuous Flow Photooxidative Degradation of Azo Dyes with Biomass-Derived Carbon Dots, ChemPhotoChem, 2023
–
Simon, Kevin and Znidar, Desiree and Boutet, Julien and Guillamot, G{\’e}rard and Lenoir, Jean-Yves and Dallinger, Doris and Kappe, C. Oliver, Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode, Organic Process Research & Development, 2023
–
Ryan, Ailbhe A. and Dempsey, Seán D. and Smyth, Megan and Fahey, Karen and Moody, Thomas S. and Wharry, Scott and Dingwall, Paul and Rooney, David W. and Thompson, Jillian M. and Knipe, Peter C. and Muldoon, Mark J., Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid, Organic Process Research & Development
–
Sagmeister, Peter and Kaldre, Dainis and Sedelmeier, Joerg and Moessner, Christian and P{\”u}ntener, Kurt and Kummli, Dominique and Williams, Jason D. and Kappe, C. Oliver, Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics, Organic Process Research & Development, 2021
–
Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphaël Robiette,
and Jean-Christophe M. Monbaliu, A modular, low footprint
and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones,
Green Chemistry, Feb 2021.
–
Mellisa B. Sagandira, Cloudius R. Sagandira, and Paul Watts, Continuous flow synthesis of xylidines
via biphasic nitration of xylenes and nitro-reduction, Journal of Flow Chemistry, Jan 2021.
–
Baldan, Marco and Blauth, Sebastian and Bošković, Dušan and Leithäuser, Christian and Mendl, Alexander and Radulescu, Ligia and Schwarzer, Maud and Wegner, Heinrich and Bortz, Michael, Continuous Synthesis of Diazo Acetonitrile: From Experiments to Physical and Grey-Box Modeling, Chemie Ingenieur Technik, 2024
–
Federico Florit, Anirudh M. K. Nambiar, Christopher P. Breen, Timothy F. Jamison, and Klavs F. Jensen, Design of dynamic trajectories for efficient and data-rich exploration of flow reaction design spaces, React. Chem. Eng., Sept 2021.
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Michaela Wernik, Gellért Sipos, Balázs Buchholcz, Ferenc Darvas, Zoltán Novák, Sándor B. Ötvös, and C. Oliver Kappe, Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor, Green Chemistry, July 2021.
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Baldassarre Venezia, Luca Panariello, Daniel Biri, Juhun Shin, Spyridon Damilos, Anand N.P. Radhakrishnan, Chris Blackman, Asterios Gavriilidis, Catalytic Teflon AF-2400 membrane reactor with adsorbed ex situ synthesized Pd-based nanoparticles for nitrobenzene hydrogenation, Catalysis Today, Feb 2021.
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Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphaël Robiette, and Jean-Christophe M. Monbaliu, A modular, low footprint and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones, Green Chemistry, Feb 2021.
–
Hoang Khang Bui, Ki Yoon Kim, Hyeonjin Kim, Jae‐Pyoung Ahn, Taekyung Yu, and Tae Seok Seo, Total Integration of the Sample Injection, Microdroplet Reaction, Phase Separation, Real‐Time Optical Detection, and Recovery of Diverse Silver–Gold Bimetallic Nanoalloys in a Continuous Process, Particle., Dec 2020.
–
Ke Wu, Gaowei Wu, Alexander J. MacRobert, Elaine Allan, Asterios Gavriilidis, and Ivan P. Parkin, Ultra high molecular weight polyethylene with incorporated crystal violet and gold nanoclusters is antimicrobial in low intensity light and in the dark, Mater. Adv.., Nov 2020.
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Gi Byoung Hwang, Gaowei Wu, Juhun Shin, Luca Panariello, Victor Sebastian, Kersti Karu, Elaine Allan, Asterios Gavriilidis, and Ivan P. Parkin, Continuous Single-Phase Synthesis of [Au25(Cys)18] Nanoclusters and their Photobactericidal Enhancement, ACS Appl. Mater. Interfaces, Oct 2020.
–
Elena Herrero-Gomez, Cornelis H. M. van der Loo, Lena Huck, Ana Rioz-Martínez, Nandell F. Keene, Bryan Li, Kees Pouwer, Christophe Allais, Photo-oxidation of Cyclopentadiene Using Continuous Processing: Application to the Synthesis of (1R,4S)-4-Hydroxycyclopent-2-en-1-yl Acetate, Org. Process Res. Dev., April 2020.
–
Cristian Rosso, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets, Wouter Debrouwer, Bartholomäus Pieber and C. Oliver Kappe, An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings, Reaction Chemistry and Engineering, Feb 2020.
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Romaric Gérardy, Julien Estager, Patricia Luis, Damien P. Debeckerd and Jean-Christophe M. Monbaliu, Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions, Catalysis Science & Technology, Jan 2020.
–
Baldassarre Venezia, Mark Douthwaite, Gaowei Wu, Meenakshisundaram Sankar, Peter Ellis, Graham J.Hutchings, Asterios Gavriilidis, Slurry loop tubular membrane reactor for the catalysed aerobic oxidation of benzyl alcohol, Chemical Engineering Journal, Dec 2019.
–
He Huang, Gi Byoung Hwang, Gaowei Wu Kersti Karu, Hendrik Du Toit, Han Wu, June Callison, Ivan P. Parkin, Asterios Gavriilidis, Rapid synthesis of [Au25(Cys)18] nanoclusters via carbon monoxide in microfluidic liquid-liquid segmented flow system and their antimicrobial performance, Chemical Engineering Journal, Oct 2019.
–
Róbert Örkényi1, Continuous Purifications in Multistep Continuous Flow Synthesis of Pharmaceutical Compounds, Poster Presentation, Sep 2019.
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Anna Pekkari, Zafer Say, Arturo Susarrey-Arce, Christoph Langhammer, Hanna Härelin, Victor Sebastian, Kasper Moth-Poulsen, Continuous Microfluidic Synthesis of Pd Nanocubes and PdPt Core–Shell Nanoparticles and Their Catalysis of NO2 Reduction, ACS Appl. Mater. Interfaces, Aug 2019.
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Alexander Steiner Jason D. Williams Juan A Rincón Oscar de Frutos Carlos Mateos C. Oliver Kappe, Implementing Hydrogen Atom Transfer (HAT) Catalysis for Rapid and Selective Reductive Photoredox Transformations in Continuous Flow, European Journal of Organic Chemistry, July 2019.
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C Rosso, JD Williams, G Filippini, M Prato, CO Kappe, Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate, Organic Letters, June 2019.
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Gaowei Wu, Enhong Cao, Peter Ellis, Achilleas Constantinou, Simon Kuhn, Asterios Gavriilidis, Continuous flow aerobic oxidation of benzyl alcohol on Ru/Al2O3 catalyst in a flat membrane microchannel reactor: An experimental and modelling study, Chemical Engineering Science, Volume 201, 29 June 2019, Pages 386-396.
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Conor Waldron, Arun Pankajakshan, Marco Quaglio, Enhong Cao, Federico Galvanin, and Asterios Gavriilidis, An autonomous microreactor platform for the rapid identification of kinetic models, React. Chem. Eng., April 2019.
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Victor-Emmanuel Horst Kassin, Romaric Gérardy, Thomas Toupy, Diégo Collin, Elena Salvadeo, François Toussaint, Kristof Van Hecke and Jean-Christophe M Monbaliu Expedient Preparation of Active Pharmaceutical Ingredient Ketamine under Sustainable Continuous Flow Conditions, Green Chemistry, March 2019.
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René Lebl, David Cantillo, and C. Oliver Kappe, Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions, React. Chem. Eng., Jan 2019.
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Jason D. Williams, Momoe Nakano, Romaric Gérardy, Juan A. Rincón, Óscar de Frutos, Carlos Mateos, Jean-Christophe M. Monbaliu, and C. Oliver Kappe, Finding the Perfect Match: A Combined Computational and Experimental Study toward Efficient and Scalable Photosensitized [2 + 2] Cycloadditions in Flow, Organic Process Research and Development Jan 2019.
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Chengwen Xue, Jiesheng Li, Jin Ping Lee, Ping Zhang and Jie Wu, Continuous amination of aryl/heteroaryl halides using aqueous ammonia in a Teflon AF-2400 tube-in-tube micro-flow reactor, Reaction Chemistry and Engineering November 2018.
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Manuel Köckinger, Christopher A. Hone, Bernhard Gutmann, Paul Hanselmann, Michael Bersier, Ana Torvisco, and C. Oliver Kappe, Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source, Org. Process Res. Dev. November 2018.
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Zhiguo Wang, Romaric Gérardy, Guillaume Gauron, Christian Damblon and Jean-Christophe M Monbaliu, Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions, Reaction Chemistry & Engineering Oct 2018.
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Irini Abdiaj, Clemens R. Horn, and Jesus Alcazar, Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring, The Journal of Organic Chemistry Oct 2018.
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Gaowei Wu, Enhong Cao, Peter Ellis, Achilleas Constantinou, Simon Kuhn, Asterios Gavriilidis, Development of a flat membrane microchannel packed-bed reactor for scalable aerobic oxidation of benzyl alcohol in flow, Chemical Engineering Journal Oct 2018.
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Nelly Ntumba Tshibalonza, Romaric Gérardy, Zouheir Alsafra, Gauthier Eppeb and Jean-Christophe M. Monbaliu,
A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol, Green Chemistry Sep 2018.
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Carlos Mendoza Noémie Emmanuel Carlos Paez Laurent Dreesen Jean-Christophe M. Monbaliu, and Benoît Heinrichs, Improving Continuous Flow Singlet Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles, ChemPhotoChem Aug 2018.
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Nathalie Ollivier, Thomas Toupy, Ruben C. Hartkoorn, Rémi Desmet, Jean-Christophe M. Monbaliu & Oleg Melnyk, Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides, Nature Communications July 2018.
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Carlos Mendoza, Noémie Emmanuel, Carlos Alberto Páez, Laurent Dreesen, Jean-Christophe M. Monbaliu, Benoît Heinrichs, Transitioning from conventional batch to microfluidic processes for the efficient singlet oxygen photooxygenation of methionine, J. Photochemistry Dec 2017.
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Joshua Britton and Timothy F Jamison, The assembly and use of continuous flow systems for chemical synthesis , Nature Protocols Oct 2017.
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Amanda C. Wicker, Frank A. Leibfarth and Timothy F. Jamison, Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules, Polym. Chem. Sep 2017.
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Gaowei Wu, Enhong Cao, Simon Kuhn, and Asterios Gavriilidis, A Novel Approach for Measuring Gas Solubility in Liquids Using a Tube-in-Tube Membrane Contactor, Chem. Eng. Technol. Aug 2017.
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Róbert Örkényi, Gyula Beke, Eszter Riethmüller, Zoltán Szakács, János Kóti, Ferenc Faigl, János Éles, and István Greiner, Environment-Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques, Eur. J. Org. Chem. Aug 2017.
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Paul Watts and Cloudius Sagandira, Synthesis of amines, carbamates and amides via multi-step continuous flow synthesis , Eur. J. Org. Chem. Aug 2017.
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Noémie Emmanuel, Carlos Mendoza, Marc Winter, Clemens R. Horn, Alessandra Vizza, Laurent Dreesen, Benoît Heinrichs, and Jean-Christophe M. Monbaliu, Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions Org. Process Res. Dev. July 2017.
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Isabel Ortiz de Solorzano, Martin Prieto, Gracia Mendoza, Teresa Alejo, Silvia Irusta, Manuel Arruebo, and Victor Sebastian, Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulphide Nanoparticles ACS Appl. Mater. Interfaces Aug 2016.
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Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and extraction Org. Process Res. Dev. Aug 2016.
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Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam, Jie Chen, Timothy F. Jamison, Klavs F. Jensen, Jean-Christophe M. Monbaliu, Allan S. Myerson, Eve M. Revalor, David R. Snead, Torsten Stelzer, Nopphon Weeranoppanant, Shin Yee Wong, Ping Zhang, On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system Science April 2016.
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Achilleas Constantinou, Gaowei Wu, Albert Corredera, Peter Ellis, Donald Bethell, Graham J. Hutchings, Simon Kuhn, and Asterios Gavriilidis, Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed-Bed Reactor Organic Process Research & Development December 2015.
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Chunhui Dai, David R. Snead, Ping Zhang, and Timothy F. Jamison, Continuous-Flow Syn and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities J. Flow Chem. July 2015.
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David Snead, Timothy Jamison, A Three‐Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous‐Flow Processing. AngewandteChemie, Dec 2014.
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